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PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation

Identifieur interne : 000259 ( Main/Exploration ); précédent : 000258; suivant : 000260

PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation

Auteurs : Graeme Sargent ; Tim Van Zutphen ; Tatiana Shatseva ; Ling Zhang ; Valeria Di Giovanni ; Robert Bandsma ; Peter Kijun Kim

Source :

RBID : PMC:5021090

Abstract

Sargent et al. identify the E3 ubiquitin ligase PEX2 as the causative agent of mammalian pexophagy. During amino acid starvation, PEX2 expression increases to ubiquitinate peroxisomal membrane proteins and signal peroxisome degradation by autophagy.


Url:
DOI: 10.1083/jcb.201511034
PubMed: 27597759
PubMed Central: 5021090


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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